RILP Antibody

• Background :

  RILP Antibody: The Rab interacting lysosomal protein (RILP) is lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. It is thought that RILP is a downstream effector of RAB7 and both proteins act together in the regulation of late endocytic traffic. Overexpression of RILP caused enlarged lysosomes that are more centrally located in the cell suggesting that RILP may also be involved in the regulation of lysosomal morphology. Other evidence suggests that RILP may play a role in the biogenesis of multivesicular bodies.

• NCBI Gene ID :

  83547

• Swiss Prot :

  Q96NA2

• Accession Number :

  NP_113618

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Homeostasis

• Purification :

  RILP Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1288 - A20 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  RILP Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  RILP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  RILP

• Positive Control 2 :

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name :

  Rab interacting lysosomal protein

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Cantalupo G, Alifano P, Roberti V, et al. Rab-interacting lysosomal protein (RILP) : the Rab7 effector required for transport to lysosomes. EMBO J. 2001; 20:683-93.

• Background Reference 02 :

  Wang T, Wong KK, and Hong W. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. Mol. Biol. Cell 2004; 15:815-26.

• Background Reference 03 :

  Progida C, Spinosa MR, De Luca A, et al. RILP interacts with the VPS22 component of the ESCRT-II complex. Biochem. Biophys. Res. Commun. 2006; 347:1074-9.

• Other Product Names :

  RILP Antibody: PP10141, Rab-interacting lysosomal protein

• Tested Applications :

  ELISA, WB, ICC, IF

• Protein ID :

  93204881

• Physical Properties :

  Liquid