FOXRED2 Antibody

CAT: 0223-6761-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6761-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
FOXRED2 Antibody: FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD) . It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.
NCBI Gene ID
80020
Swiss Prot
Q8IWF2
Accession Number
No.Q8IWF2
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
FOXRED2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1302 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (94%)
Buffer
FOXRED2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
FOXRED2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
FOXRED2
NCBI Official Name
FAD-dependent oxidoreductase domain containing 2
NCBI Organism
Homo sapiens
Background Reference 01
Riemer J, Appenzeller-Herzog C, Johansson L, et al. A luminal flavoprotein in endoplasmic reticulum-associated degradation. Proc. Natl. Acad. Sci. USA 2009; 106:14831-6.
Background Reference 02
Riemer J, Hansen HG, Appenzeller-Herzog C, et al. Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. PLoS One 2011; 6:e17037
Background Reference 03
Calvo SE, Tucker EJ, Compton AG, et al. High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nat. Genet. 2010; 42:851-8.
Other Product Names
FOXRED2 Antibody: ERFAD, ERFAD, FAD-dependent oxidoreductase domain-containing protein 2, Endoplasmic reticulum flavoprotein associated with degradation
Tested Applications
ELISA, WB, IF
Protein ID
156139139
Physical Properties
Liquid

Related Products

CatalogName
6761PFOXRED2 Peptide
13-609FOXRED1 Antibody
45-607FOXD2 Antibody
27-402FOXD2 Antibody
16-113FOXR2 Antibody
29-806FOXR2 Antibody
45-607PFOXD2 Peptide
64-160WAS Antibody
13-349WAS Antibody
60-596WAS Antibody

Alternative Products

CatalogName
25460FOXRED2 Antibody
MBS2560634-01FOXRED2 Polyclonal Antibody
abx317501-01FOXRED2 Antibody (Biotin)
abx317499-01FOXRED2 Antibody (HRP)
A12703Anti-FOXRED2 Antibody
APR06747GPolyclonal FOXRED2 Antibody
abx317500-01FOXRED2 Antibody (FITC)
TA320025FOXRED2 Rabbit Polyclonal Antibody
NBP2-81943Rabbit Polyclonal FOXRED2 Antibody
A61247-100UGFOXRED2 Antibody, HRP conjugated

Popular Products