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NKX2-2 Antibody

CAT: 0223-6743-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6743-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NKX2-2 Antibody: NKX2-2 (NK2 homeobox 2) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-2 is crucial in the development of pancreatic islet cell differentiation and activates the ghrelin-promoter in these cells. NKX2-2 is expressed at the onset of pancreatic epithelium formation and becomes restricted to mature α -, β - and PP cells, and in NKX2-2-null mice embryos, all β -cells and most a-cells are replaced by ghrelin-positive cells. NKX2-2 is also thought to be involved in ventral neuronal patterning and floor plate development and commissural axon guidance.
NCBI Gene ID
4821
Swiss Prot
O95096
Accession Number
NP_002500
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
NKX2-2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1465 - Rat Kidney Tissue Lysate
Concentration
1 mg/mL
Buffer
NKX2-2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NKX2-2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
NKX2-2 antibody is predicted to not cross-react with other NK2 homeobox family members.
Symbol
NKX2-2
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
NK2 homeobox 2
NCBI Organism
Homo sapiens
Background Reference 01
Sussel L, Kalamaras J, Hartigan-O'Connor DJ, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 1998; 125:2213-21
Background Reference 02
Prado CL, Pugh-Bernard AE, Elghazi L, et al. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc. Natl. Acad. Sci. 2004; 101:2924-9.
Background Reference 03
Hill JT, Chao CS, Anderson KR, et al. Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol. Endocrinol. 2010; 381-90.
Background Reference 04
Briscoe J, Sussel L, Serup P, et al. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signaling. Nature 1999; 398:622-7.
Other Product Names
NKX2-2 Antibody: NKX2B, NKX2.2, NKX2B, Homeobox protein NK-2 homolog B
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4505401
Physical Properties
Liquid

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