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UPK1B Antibody

CAT: 0223-6499-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6499-01Size:0.02 mg
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Background
UPK1B Antibody: Uroplakin-1B (UPK1B) is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. UPK1B is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins and may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
NCBI Gene ID
7348
Swiss Prot
O75841
Accession Number
NP_008883
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
UPK1B Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
UPK1B Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
UPK1B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of UPK1B are known to exist; this antibody will recognize both isoforms. UPK1B antibody is predicted to not cross-react with other tetraspanin protein family members.
Symbol
UPK1B
NCBI Official Name
Uroplakin 1B
NCBI Organism
Homo sapiens
Background Reference 01
Yu J, Lin JH, Wu XR, et al. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. J. Cell Biol. 1994; 125:171-82.
Background Reference 02
Wu XR, Kong XP, Pellicer A, et al. Uroplakins in urothelial biology, function, and disease. Kidney Int. 2009; 75:1153-65
Background Reference 03
Sun TT, Zhao H, Provet J, et al. Formation of asymmetric unit membrane during urothelial differentiation. Mol. Biol. Rep. 1996; 23:3-11.
Other Product Names
UPK1B Antibody: UPIB, UPK1, TSPAN20, Uroplakin-1b, Tetraspanin-20, UP1b
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
49619237
Physical Properties
Liquid

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