EI24 Antibody

• Background :

  EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER) . It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.

• NCBI Gene ID :

  9538

• Swiss Prot :

  O14681

• Accession Number :

  NP_004870

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis

• Purification :

  EI24 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1464 - Rat Liver Tissue Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine: (95%)

• Buffer :

  EI24 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  EI24 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  At least two isoforms of EI24 are known to exist; this antibody will only detect the larger isoform.

• Symbol :

  EI24

• NCBI Official Name :

  Etoposide induced 2.4 mRNA

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Lehar SM, Nacht M, Jacks T, et al. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene 1996; 12:1181-7.

• Background Reference 02 :

  Gu Z, Flemington C, Chittenden T, et al. ei24, a p53 response gene involved in growth suppression and apoptosis. Mol. Cell Biol. 2000; 20:233-41

• Background Reference 03 :

  Zhao X, Ayer RE, Davis SL, et al. Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness. Cancer Res. 2005; 65:2125-9.

• Background Reference 04 :

  Mazumder D, Mitra S, Singh RK, et al. Inactivation of CHEK1 and EI24 are associated with the development of invasive cervical carcinoma: clinical and prognostic implications. Int. J. Cancer 2010; epub

• Other Product Names :

  EI24 Antibody: EPG4, PIG8, TP53I8, p53-induced gene 8 protein

• Tested Applications :

  ELISA, WB, IHC-P

• Protein ID :

  55956766

• Physical Properties :

  Liquid