Products for Research Use Only
RegisterLogin

GEMC1 Antibody

CAT: 0223-6385-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-6385-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
GEMC1 Antibody: The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
NCBI Gene ID
647309
Swiss Prot
A6NCL1
Accession Number
NP_001140158
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
GEMC1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1401 - Mouse Heart Tissue Lysate
Concentration
1 mg/mL
Buffer
GEMC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GEMC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
GEMC1
NCBI Official Name
Geminin coiled-coil domain-containing protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Piergiovanni G, Costanzo V. GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication. Cell Cycle 2010; 9:3662-6.
Background Reference 02
McGarry TJ and Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 1998; 93:1043-53.
Background Reference 03
Rowles A and Blow JJ. Chromatin proteins involved in the initiation of DNA replication. Curr. Opin. Genet. Dev. 1997; 7:152-7.
Background Reference 04
Balestrini A, Cosentino C, Errico A, et al. GEMC1 is a TopBP1 interacting protein required for chromosomal DNA replication. Nat. Cell Biol. 2010; 12:484-91.
Other Product Names
GEMC1 Antibody: GEMC1, GEMC1, Geminin coiled-coil domain-containing protein 1
Tested Applications
ELISA, WB
Protein ID
226442751
Physical Properties
Liquid

Related Products

CatalogName
6385PGEMC1 Peptide
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody
19-580FABP3 Antibody
15-580POMGNT2 Antibody

Alternative Products

CatalogName
25320GEMC1 Antibody
MBS9234710-01GEMC1 Polyclonal Antibody
GTR17738813-01GEMC1 Rabbit Polyclonal Antibody
NBP2-41131-0.025mgRabbit Polyclonal GEMC1 Antibody
A17100Anti-GEMC1 GMNC Antibody
GTR19005419GEMC1 Antibody Blocking Peptide
SL13332R-01Rabbit Anti-GEMC1 antibody
GTR17814830GEMC1 Rabbit Polyclonal Antibody (APC)
NBP2-41131BRabbit Polyclonal GEMC1 Antibody [Biotin]
GTR18498330GEMC1 Rabbit Polyclonal Antibody (BF350)

Popular Products