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Translin Antibody

CAT: 0223-6369-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6369-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Translin Antibody: Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
NCBI Gene ID
7247
Swiss Prot
Q15631
Accession Number
NP_004613
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
Translin Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1462 - Rat Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (100%)
Buffer
Translin Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Translin antibody can be stored at 4 ˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of Translin are known to exist; this antibody will detect both.
Symbol
TSN
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Translin
NCBI Organism
Homo sapiens
Background Reference 01
Aoki K, Susuki K, Sugano T, et al. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. Nat. Genet. 1995; 10:167-74.
Background Reference 02
Li Z, Wu Y, and Baraban JM. The Translin/Trax RNA binding complex: clues to function in the nervous system. Biochim. Biophys. Acta 2008; 1779:479-85
Other Product Names
Translin Antibody: C3PO, RCHF1, TBRBP, TRSLN, BCLF-1, REHF-1, Translin, Component 3 of promoter of RISC, C3PO
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4759270
Physical Properties
Liquid

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