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ZIMP7 Antibody

CAT: 0223-6235-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6235-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ZIMP7 Antibody: ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription) -like protein and a transcriptional coactivator. ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity and this activity is inhibited by the N-terminus in the full-length ZIMP7. ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhances Androgen Receptor (AR) - mediated transcription. The interaction between ZIMP7 and SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification.
NCBI Gene ID
83637
Swiss Prot
Q8NF64
Accession Number
Q8NF64
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
ZIMP7 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
ZIMP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ZIMP7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least four isoforms are known to exist. ZIMP7 antibody is predicted to not cross-react with other PIAS protein family members.
Symbol
ZMIZ2
NCBI Official Name
Zinc finger, MIZ-type containing 2
NCBI Organism
Homo sapiens
Background Reference 01
Huang CY, Beliakoff J, Li X, et al. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol. Endocrinol. 2005; 19:2915-29
Background Reference 02
Ueki N, Oda T, Kondo M, et al. Selection system for genes encoding nuclear-targeted proteins. Nat. Biotechnol. 1998; 16:1338-42.
Background Reference 03
Beliakoff J and Sun Z. Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators. Nucl. Recept. Signal. 2006; 4:e017
Background Reference 04
Peng Y, Lee J, Zhu C, et al. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. J. Biol. Chem. 2010; 285:11465-75.
Other Product Names
ZIMP7 Antibody: NET27, ZIMP7, hZIMP7, TRAFIP20, KIAA1886, HRIHFB2007, Zinc finger MIZ domain-containing protein 2, PIAS-like protein Zimp7
Tested Applications
ELISA, WB
Protein ID
54607108
Physical Properties
Liquid

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