Products for Research Use Only
RegisterLogin

TM4SF1 Antibody

CAT: 0223-6229-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-6229-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
TM4SF1 Antibody: TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.
NCBI Gene ID
4071
Swiss Prot
P30408
Accession Number
NP_055035
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
TM4SF1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1302 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
TM4SF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TM4SF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of TM4SF1 are known to exist; this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.
Symbol
TM4SF1
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Transmembrane 4 L six family member 1
NCBI Organism
Homo sapiens
Background Reference 01
Marken JS, Schieven GL, Hellstrom I, et al. Cloning and expression of the tumor-associated antigen L6. Proc. Natl. Acad. Sci. USA 1992; 89:3503-7
Background Reference 02
Romanska HM and Berditchevski F. Tetraspanins in human epithelial malignancies. J. Pathol. 2011; 223:4-14
Background Reference 03
Shih SC, Zukauskas A, Li D, et al. The L6 TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res. 2009; 69:3272-7.
Other Product Names
TM4SF1 Antibody: L6, H-L6, M3S1, TAAL6, Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
21265101
Physical Properties
Liquid

Related Products

CatalogName
6229PTM4SF1 Peptide
57-648TM4SF18 Antibody
26-142TM4SF4 Antibody
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody

Alternative Products

CatalogName
A30434-100ULTM4SF1 Antibody

Popular Products