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RHAMM Antibody

CAT: 0223-6189-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6189-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RHAMM Antibody: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.
NCBI Gene ID
3161
Swiss Prot
O75330
Accession Number
NP_036617
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
KO Validation (Figure 1) : Anti-RHAMM antibodies (6189) specificity was further verified by RHAMM specific knockout. RHAMM signal was not detected in RHAMM knockout HeLa cells as compared to that in control wild type cells. KO Validation
Field of Research
Cancer, Cell Cycle
Purification
RHAMM Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1475 - Rat Stomach Tissue Lysate
Concentration
1 mg/mL
Buffer
RHAMM Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RHAMM antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
HMMR
Positive Control 2
Cat. No. 10-801 - Human Stomach Tissue Slide
NCBI Official Name
Yaluronan-mediated motility receptor
NCBI Organism
Homo sapiens
Background Reference 01
Hardwick C, Hoare K, Owens R, et al. Molecular cloning of a novel hyaluronan receptor that promotes tumor cell motility. J. Cell Biol. 1992; 117:1343-50.
Background Reference 02
Samuel SK, Hurta RA, Spearman MA, et al. TGF-beta 1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronan. J. Cell Biol. 1993; 123:749-58.
Background Reference 03
Hall CL, Yang B, Yang X, et al. Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation. Cell 1995; 82:19-26.
Background Reference 04
Maxwell CA, McCarthy J, and Turley E. Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions? J. Cell Sci. 2008; 121:925-32.
Other Product Names
RHAMM Antibody: CD168, IHABP, RHAMM, Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
217272802
Physical Properties
Liquid

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