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PION Antibody

CAT: 0223-6161-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6161-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PION Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99) . The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patient's brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.
NCBI Gene ID
54103
Swiss Prot
A4D1B5
Accession Number
NP_059135
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
PION Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
PION Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PION antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.
Symbol
PION
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Pigeon homolog (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Ponte P, Gonzalez-DeWhitt P, Schilling J, et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature1988; 331:525-77.
Background Reference 02
Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol.1994; 10:373-403.
Background Reference 03
He G, Luo W, Li P, et al. Gamma-secretase activating protein is a therapeutic target for Alzheimer's diease. Nature2010; 467:95-9.
Other Product Names
PION Antibody: PION, PION, Gamma-secretase-activating protein, Protein pigeon homolog, GSAP
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
148612805
Physical Properties
Liquid

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