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ZIP5 Antibody

CAT: 0223-6089-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6089-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ZIP5 Antibody: The zinc transporter ZIP5, also known as SLC39A5, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP5 is closely related to ZIP4, and is found in many of the same tissues, including intestine, pancreas, liver, and kidney, but unlike ZIP4, ZIP5 localizes to the basolateral membrane in kidney cells and its activity is not downregulated by zinc repletion. Recent evidence suggests that ZIP4 and ZIP5 are reciprocally regulated, with translation of ZIP5 mRNA decreasing and ZIP5 protein being rapidly internalized and degraded in response to zinc deficiency.
NCBI Gene ID
283375
Swiss Prot
Q6ZMH5
Accession Number
NP_001128667
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
ZIP5 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
ZIP5 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ZIP5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SLC39A5
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Solute carrier family 39 (metal ion transporter), member 5
NCBI Organism
Homo sapiens
Background Reference 01
Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50.
Background Reference 02
Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
Background Reference 03
Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
Background Reference 04
Wang F, Kim BE, Petris MJ, et al. The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J. Biol. Chem.2004; 279:51433-41.
Other Product Names
ZIP5 Antibody: ZIP5, LZT-Hs7, ZIP5, Zinc transporter ZIP5, Solute carrier family 39 member 5, ZIP-5
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
206597541
Physical Properties
Liquid

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