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SYNPO2 Antibody

CAT: 0223-6051-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6051-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SYNPO2 Antibody: SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.
NCBI Gene ID
171024
Swiss Prot
Q9UMS6
Accession Number
NP_597734
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
SYNPO2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate
Concentration
1 mg/mL
Buffer
SYNPO2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SYNPO2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SYNPO2
NCBI Official Name
Synaptopodin 2
NCBI Organism
Homo sapiens
Background Reference 01
Weins A, Schwarz K, Faul C, et al. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J. Cell Biol.2001; 155:393-404.
Background Reference 02
Shroeter MM, Beall B, Heid HW, et al. In vitro characterization of native mammalian smooth-muscle protein synaptopodin. Biosci. Rep.2008; 195-203.
Background Reference 03
Lin F, Yu YP, Woods J, et al. Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers. Am. J. Path.2001; 5:1603-12.
Background Reference 04
De Ganck A, De Corte V, Bruyneel E, et al. Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. Int. J. Oncol.2009; 34:1403-9.
Other Product Names
SYNPO2 Antibody: Synaptopodin-2, Genethonin-2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
193083183
Physical Properties
Liquid

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