PLAC1 Antibody

• Background:

  PLAC1 Antibody: PLAC1 was initially identified as a protein expressed specifically in the placenta and other cells derived from the trophoblast lineage during embryonic development, but has also been found to be expressed ectopically in a wide range of human malignancies, particularly breast cancers. PLAC1 is a membrane-associated protein that is thought to serve a receptor-like function modulating cell-cell or ligand receptor interactions unique to the maternal-placental interface. Decreased expression of PLAC1 is associated with decreased expression of cyclin D1 and reduced expression of AKT kinase, which, combined with the fact that PLAC1 is expressed on the surface of cancer cells, suggests that PLAC1 may be an effective candidate for immunotherapeutic treatments of cancer.

• NCBI Gene ID:

  10761

• Swiss Prot:

  Q9HBJ0

• Accession Number:

  NP_068568

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  PLAC1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1309 - Human Placenta Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  PLAC1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PLAC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  PLAC1

• Positive Control 2:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Placenta-specific 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cocchia M, Humber R, Pantano S, et al. PLAC1, an Xq26 gene with placenta-specific expression. Genomics2000; 68:305-12.

• Background Reference 02:

  Koslowski M, Sahin U, Mitnacht-Kraus R, et al. A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes. Cancer Res.2007; 67:9528-34.

• Background Reference 03:

  Fant M, Weisoly DL, Cocchia M, et al. PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. Mol. Reprod. Dev.2002; 63:430-6.

• Other Product Names:

  PLAC1 Antibody: CT92, OOSP2L, Placenta-specific protein 1

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  11496283

• Physical Properties:

  Liquid