PLAC1 Antibody

CAT: 0223-6015-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6015-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PLAC1 Antibody: PLAC1 was initially identified as a protein expressed specifically in the placenta and other cells derived from the trophoblast lineage during embryonic development, but has also been found to be expressed ectopically in a wide range of human malignancies, particularly breast cancers. PLAC1 is a membrane-associated protein that is thought to serve a receptor-like function modulating cell-cell or ligand receptor interactions unique to the maternal-placental interface. Decreased expression of PLAC1 is associated with decreased expression of cyclin D1 and reduced expression of AKT kinase, which, combined with the fact that PLAC1 is expressed on the surface of cancer cells, suggests that PLAC1 may be an effective candidate for immunotherapeutic treatments of cancer.
NCBI Gene ID
10761
Swiss Prot
Q9HBJ0
Accession Number
NP_068568
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
PLAC1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1309 - Human Placenta Tissue Lysate
Concentration
1 mg/mL
Buffer
PLAC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PLAC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
PLAC1
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Placenta-specific 1
NCBI Organism
Homo sapiens
Background Reference 01
Cocchia M, Humber R, Pantano S, et al. PLAC1, an Xq26 gene with placenta-specific expression. Genomics2000; 68:305-12.
Background Reference 02
Koslowski M, Sahin U, Mitnacht-Kraus R, et al. A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes. Cancer Res.2007; 67:9528-34.
Background Reference 03
Fant M, Weisoly DL, Cocchia M, et al. PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. Mol. Reprod. Dev.2002; 63:430-6.
Other Product Names
PLAC1 Antibody: CT92, OOSP2L, Placenta-specific protein 1
Tested Applications
ELISA, WB, ICC, IF
Protein ID
11496283
Physical Properties
Liquid

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