Products for Research Use Only
RegisterLogin

KPNA6 Antibody

CAT: 0223-5991-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-5991-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
KPNA6 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
NCBI Gene ID
23633
Swiss Prot
O60684
Accession Number
CAH71948
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
KPNA6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (92%)
Buffer
KPNA6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KPNA6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
KPNA6
Positive Control 2
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
Karyopherin alpha 6 (importin alpha 7)
NCBI Organism
Homo sapiens
Background Reference 01
Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene Expr.1997; 7:61-72.
Background Reference 02
Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem.2003; 278: 51937-49.
Background Reference 03
Kohler MC, Fiebeler M, Hartwig S, et al. Evidence for distinct substrate specificity of importin alpha family members in nuclear protein import. Mol. Cell. Biol.1999; 19:7782-91.
Background Reference 04
Quensal C, Friedrich B, Sommer T, et al. In vivo analysis of importin a proteins reveals cellular proliferation inhibition and substrate specificity. Mol. Cell. Biol.2004; 24:10246-55.
Other Product Names
KPNA6 Antibody: IPOA7, KPNA7, IPOA7, Importin subunit alpha-7, Karyopherin subunit alpha-6
Tested Applications
ELISA, WB, IF
Protein ID
55664992
Physical Properties
Liquid

Related Products

CatalogName
46-860PKPNA6 Peptide
5991PKPNA6 Peptide
45-813KPNA3 Antibody
5981-01mgKPNA1 Antibody
5983-01mgKPNA2 Antibody
6655-01KPNA5 Antibody
5985-01KPNA3 Antibody
5981-002mgKPNA1 Antibody
45-814KPNA4 Antibody
26-912KPNA4 Antibody

Alternative Products

CatalogName
CSB-PA012488GA01HUKPNA6 Antibody

Popular Products