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KPNA3 Antibody

CAT: 0223-5985-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5985-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KPNA3 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA3, the alpha subunit 3 of karyopherin, is silimar to human KPNA2, suggesting that KPNA3 may be involved in the nuclear transport system. It is ubiquitously expressed and recent studies have shown that human KPNA3 may be associated with schizophrenia.
NCBI Gene ID
3839
Swiss Prot
O00505
Accession Number
NP_002258
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
KPNA3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
KPNA3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KPNA3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
KPNA3
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
Positive Control 3
Cat. No. 17-207 - EL4 Cell Slide
NCBI Official Name
Karyopherin alpha 3 (importin alpha 4)
NCBI Organism
Homo sapiens
Background Reference 01
Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene Expr.1997; 7:61-72.
Background Reference 02
Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem.2003; 278: 51937-49.
Background Reference 03
Takeda S, Fujiwara T, Shimizu F, et al. Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1. Cytogenet. Cell Genet.1997; 76:87-93.
Background Reference 04
Zhang H, Ju G, Wei J, et al. A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia. Neurosci. Lett.2006; 402:173-5.
Other Product Names
KPNA3 Antibody: SRP1, SRP4, IPOA4, hSRP1, SRP1gamma, QIP2, Importin subunit alpha-4, Importin alpha Q2, Qip2
Tested Applications
ELISA, WB, ICC, IF
Protein ID
34485722
Physical Properties
Liquid

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