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BANP Antibody

CAT: 0223-5977-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5977-01Size:0.02 mg
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Background
BANP Antibody: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-beta signaling. Furthermore, BANP can modulate NF-κ B transactivation and can inhibit tumorigenesis by regulating NF-κ B target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.
NCBI Gene ID
54971
Swiss Prot
Q8N9N5
Accession Number
NP_001167014
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
BANP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
BANP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BANP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
BANP
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
BTG3 associated nuclear protein
NCBI Organism
Homo sapiens
Background Reference 01
Birot A, Duret L, Bartholin L, et al. Identification and molecular analysis of BANP. Gene2000; 253:189-96.
Background Reference 02
Kaul R, Mukherjee S, Ahmed F, et al. Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice. Int. J. Cancer2003; 103:606-15.
Background Reference 03
Singh K, Mogare D, Giridharagopalan RO, et al. P%3 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion. PLoS One2007; 2:e660.
Background Reference 04
Signh K, Sinha S, Malonia SK, et al. Tumor suppressor SMAR1 repsses IkBa expression and inhibits p65 transactivation through matrix attachment regions. J. Biol. Chem.2009; 284:1267-78.
Other Product Names
BANP Antibody: BEND1, SMAR1, SMARBP1, BEND1, Protein BANP, BEN domain-containing protein 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
291084803
Physical Properties
Liquid

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