Products for Research Use Only
RegisterLogin

NALP7 Antibody

CAT: 0223-5963-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-5963-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
NALP7 Antibody: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β secretion and is a feedback regulator of interleukin-1β secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
NCBI Gene ID
199713
Swiss Prot
Q8WX94
Accession Number
NP_631915
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
NALP7 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1204 - K562 Cell Lysate
Concentration
1 mg/mL
Buffer
NALP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NALP7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NLRP7
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
NLR family, pyrin domain containing 7
NCBI Organism
Homo sapiens
Background Reference 01
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Background Reference 02
Kinoshita T, Wang Y, Hasegawa M, et al. PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. J. Biol. Chem.2005; 280:21720-5.
Background Reference 03
Okada K, Hirota E, Mizutani Y, et al. Oncogenic role of NALP7 in testicular seminomas. Cancer Sci.2004; 95: 949-54.
Background Reference 04
Murdoch S, Djuric U, Mazhar B, et al. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat. Genet.2006; 38: 300-2.
Other Product Names
NALP7 Antibody: HYDM, PAN7, NALP7, NOD12, PYPAF3, CLR19.4, NACHT, LRR and PYD domains-containing protein 7, Nucleotide-binding oligomerization domain protein 12
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
46049100
Physical Properties
Liquid

Related Products

CatalogName
5963PNALP7 Peptide
5957-002mgNALP4 Antibody
5965-01mgNALP8 Antibody
5961-002mgNALP6 Antibody
3037-01mgNALP1 Antibody
5959-01NALP5 Antibody
5965-002mgNALP8 Antibody
5959-01mgNALP5 Antibody
5965-01NALP8 Antibody
3037-01NALP1 Antibody

Alternative Products

CatalogName
MBS150857-01NALP7 Antibody
APR06669GPolyclonal NALP7 Antibody
GTR18226501NLRP7/NALP7 Antibody
A07838Anti-NALP7 NLRP7 Antibody
APR02778GPolyclonal NLRP7 / NALP7 Antibody (N-Terminus)
MBS2402803-01NLRP7/NALP7 Rabbit anti-Human Polyclonal Antibody
MBS152284-01NALP7 Peptide
sc-61149NALP7 siRNA (h)
sc-377190NALP7 (C-8)
sc-377190 HRPNALP7 (C-8) HRP

Popular Products