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NOD5 Antibody

CAT: 0223-5953-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5953-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NOD5 Antibody: NOD5, also known as NLRX1, is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD5 localizes to the mitochondrial outer membrane and interacts with the virus-induced signaling adapter protein VISA. Unlike a subset of NOD-like receptors (NLRs) such as NOD1 and NOD2 which trigger pro-inflammatory cascades, and other NLRs that induce the caspase 1 inflammasome in response to immune challenges, NOD5 amplifies NF-κ B and JNK pathways by inducing reactive oxygen species production.
NCBI Gene ID
79671
Swiss Prot
Q86UT6
Accession Number
NP_078894
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
NOD5 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1466 - Rat Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
NOD5 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NOD5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NLRX1
NCBI Official Name
NLR family member X1
NCBI Organism
Homo sapiens
Background Reference 01
Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci.2006; 1072:19-27.
Background Reference 02
Moore CB, Bergstralh DT, Duncan JA, et al. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature2008; 451:573-7.
Background Reference 03
Tattoli I, Carneiro LA, Jehanno M, et al. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kB and JNK pathways by inducing reactive oxygen species. EMBO Reports2008; 9:293-300.
Other Product Names
NOD5 Antibody: NOD5, NOD9, NOD26, DLNB26, CLR11.3, NOD5, NLR family member X1, Nucleotide-binding oligomerization domain protein 26
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
25777608
Physical Properties
Liquid

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