NOD2 Antibody

CAT: 0223-2513-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-2513-01Size:0.02 mg
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Background
NOD2 Antibody: Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD) . A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κ B, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease.
NCBI Gene ID
64127
Swiss Prot
Q9HC29
Accession Number
Q9HC29
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Inflammasomes
Purification
NOD2 Antibody is immunoaffinity chromatography purified IgG.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (77%), Mouse: (77%)
Buffer
NOD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NOD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
114 kDa
Fragment
IgG
Specificity
NOD2 has no cross-reaction with NOD1.
Symbol
NOD2
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Nucleotide-binding oligomerization domain containing 2
NCBI Organism
Homo sapiens
Background Reference 01
Inohara N, Koseki T, del Peso L, et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κ B. J. Biol. Chem. 1999; 274:14560-7.
Background Reference 02
Ogura Y, Inohara N, Benito A, et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κ B. J. Biol. Chem. 2001; 276:4812-8.
Background Reference 03
Hugot JP, Chamaillard M, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411:599-603.
Background Reference 04
Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411:603-6.
Other Product Names
NOD2 Antibody: CD, ACUG, BLAU, IBD1, NLRC2, NOD2B, CARD15, CLR16.3, PSORAS1, Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15
Tested Applications
ELISA, WB, ICC, IF
Protein ID
20137973
Physical Properties
Liquid

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