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NOD4 Antibody

CAT: 0223-5951-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5951-01Size:0.02 mg
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Background
NOD4 Antibody: NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-κ B and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.
NCBI Gene ID
84166
Swiss Prot
Q86WI3
Accession Number
NP_115582
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
NOD4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
NOD4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NOD4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
205 kDa
Fragment
IgG
Specificity
NOD4 antibody is predicted to not cross-react with other members of the NOD family of proteins.
Symbol
NLRC5
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
NLR family, CARD domain containing 5
NCBI Organism
Homo sapiens
Background Reference 01
Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci. 2006; 1072:19-27.
Background Reference 02
Benko S, Magalhaes JG, Philpott DJ, et al. NLRC5 limits the activation of inflammatory pathways. J. Immunol. 2010; 185:1681-91.
Background Reference 03
Meissner TB, Li A, Biswas A, et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc. Natl. Acad. Sci. USA 2010; 107:13794-9.
Background Reference 04
Cui J, Zhu L, Xia X, et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 2010; 141:483-96.
Other Product Names
NOD4 Antibody: NOD4, NOD27, CLR16.1, NOD4, Protein NLRC5, Nucleotide-binding oligomerization domain protein 27
Tested Applications
ELISA, WB, ICC, IF
Protein ID
116268109
Physical Properties
Liquid

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Alternative Products

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GTR18078828NOD4 Antibody
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GTR18226479NLRC5/NOD4 Antibody
A04481Anti-NOD4 NLRC5 Antibody
APR02777GPolyclonal NLRC5 / NOD4 Antibody (N-Terminus)
MBS153147-01NOD4 Peptide
MBS243929-01Rabbit Polyclonal to Human NLRC5 / NOD4
MBS647068-01NLRC5, NT (Protein NLRC5, Caterpiller Protein 16.1, CLR16.1, Nucleotide-binding Oligomerization Domain Protein 27, Nucleotide-binding Oligomerization Domain Protein 4, NOD27, NOD4)
N3006-17NLRC5, NT (Protein NLRC5, Caterpiller Protein 16.1, CLR16.1, Nucleotide-binding Oligomerization Domain Protein 27, Nucleotide-binding Oligomerization Domain Protein 4, NOD27, NOD4) discontinued, see 146717
146717NLRC5 (Protein NLRC5, Caterpiller Protein 16.1, CLR16.1, Nucleotide-binding Oligomerization Domain Protein 27, Nucleotide-binding Oligomerization Domain Protein 4, NOD27, NOD4, FLJ21709, FLJ39711)

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