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HVCN1 Antibody

CAT: 0223-5875-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5875-01Size:0.02 mg
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Background
HVCN1 Antibody: HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.
NCBI Gene ID
84329
Swiss Prot
Q96D96
Accession Number
NP_115745
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
HVCN1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (71%)
Buffer
HVCN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
HVCN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
HVCN1
Positive Control 2
Cat. No. 1306 - Human Spleen Tissue Lysate
NCBI Official Name
Hydrogen voltage-gated channel 1
NCBI Organism
Homo sapiens
Background Reference 01
Ramsey IS, Moran MM, Chong JA, et al. A voltage gated proton-selective channel lacking the pore domain. Nature2006; 440:1213-6.
Background Reference 02
Sasaki M, Takagi M, and Okamura Y. A voltage sensor-domain protein is a voltage-gated proton channel. Science2006; 312: 589-92.
Background Reference 03
Morgan D, Capasso M, and Musset B. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc. Natl. Acad. Sci. USA2009; 106:18022-7.
Background Reference 04
Capasso M, Bhamrah MK, Henley T, et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat. Immunol.2010;11:265-72.
Other Product Names
HVCN1 Antibody: HV1, VSOP, UNQ578/PRO1140, Voltage-gated hydrogen channel 1, Hydrogen voltage-gated channel 1, HV1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
91992155
Physical Properties
Liquid

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