SAE2 Antibody

• Background :

  SAE2 Antibody: Small ubiquitin-like modifiers (SUMOs) are a family of small, related proteins (SUMO-1/2/3/4) that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation, a major regulator of protein function in cellular processes such as nuclear transport, transcriptional regulation, apoptosis and protein stability. This sumoylation is effected by the heterodimeric enzyme SAE1/SAE2 and the SUMO-1-conjugating enzyme Ubch9. The sumoylation pathway mediated by SAE1/SAE2 is distinct from other ubiquitin-like protein (Ubl) pathways.

• NCBI Gene ID :

  10054

• Swiss Prot :

  Q9UBT2

• Accession Number :

  NP_005490

• Host :

  Rabbit

• Reactivity :

  Human

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Homeostasis

• Purification :

  SAE2 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse: (94%)

• Buffer :

  SAE2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  SAE2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  UBA2

• Positive Control 2 :

  Cat. No. 17-010 - HEK293 Cell Slide

• NCBI Official Name :

  Ubiquitin-like modifier activating enzyme 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Kamitani T, Kito K, Nguyen HP, et al. Characterization of a second member of the sentrin family of ubiquitin-like proteins. J. Biol. Chem.1998;273:11349-53.

• Background Reference 02 :

  Kim KI, Baek SH, and Chung CH. Versatile protein tag, SUMO: its enzymology and biological function. J. Cell. Physiol.2002; 191: 257-68.

• Background Reference 03 :

  Desterro JM, Rodriguez MS, Kemp GD, et al. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J. Biol. Chem.1999; 274:10618-24.

• Background Reference 04 :

  Tatham MH, Jaffray E, Vaughan OA, et al. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J. Biol. Chem.2001; 276:35368-74.

• Other Product Names :

  SAE2 Antibody: ARX, SAE2, HRIHFB2115, UBLE1B, SUMO-activating enzyme subunit 2, Anthracycline-associated resistance ARX

• Tested Applications :

  ELISA, WB, ICC, IF

• Protein ID :

  4885649

• Physical Properties :

  Liquid