DCLK1 Antibody

• Background :

  DCLK1 Antibody: DCLK1 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK1 mRNA, like that of the homologous DCLK2 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a gene that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.

• NCBI Gene ID :

  9201

• Swiss Prot :

  O15075

• Accession Number :

  NP_004725

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  DCLK1 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  DCLK1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  DCLK1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  DCLK1

• Positive Control 2 :

  Cat. No. 1463 - Rat Brain Tissue Lysate

• NCBI Official Name :

  Doublecortin-like kinase 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Sossey-Alaoui K and Srivastava AK. DCAMKL1, a brain specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX), Genomics1999; 56:121-6.

• Background Reference 02 :

  Ohmae S, Takemoto-Kimura S, Okamura M, et al. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. J. Biol. Chem.2006; 281:20427-39.

• Background Reference 03 :

  Tuy FPD, Saillour Y, Kappeler C, et al. Alternative transcripts of Dlck1 and Dlck2 and their expression in doublecortin knockout mice. Dev. Neurosci.2008; 30:171-86.

• Background Reference 04 :

  Reiner O and Coquelle FM. Missense mutations resulting in type 1 lissencephaly. Cell Mol. Life Sci.2005; 62:425-34.

• Other Product Names :

  DCLK1 Antibody: CL1, DCLK, CLICK1, DCDC3A, DCAMKL1, KIAA0369, Doublecortin domain-containing protein 3A

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  4758128

• Physical Properties :

  Liquid