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ESX1 Antibody

CAT: 0223-5597-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5597-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ESX1 Antibody: Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.
NCBI Gene ID
80712
Swiss Prot
Q8N693
Accession Number
Q8N693
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
ESX1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1313 - Human Testis Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (71%), Mouse: (71%)
Buffer
ESX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ESX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ESX1
Positive Control 2
Cat. No. 11-701 - Human Testis Tissue Slide
NCBI Official Name
ESX homeobox 1
NCBI Organism
Homo sapiens
Background Reference 01
Gehring WJ, Affolter M and Burglin T. Homeodomain proteins. Annu. Rev. Biochem.1994; 63:487-526.
Background Reference 02
Fohn LE and Behringer RR. ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis. Genomics2001; 74:105-8.
Background Reference 03
Li Y, Lemaire P and Behringer RR. ESX1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells. Dev. Biol.1997; 188:85-95.
Background Reference 04
Figueiredo AL, Salles MG, Albano RM, et al. Molecular and morphogenic analyses of expression of ESX1L in different stages of human placental development. J. Cell Mol. Med.2004; 8:545-50.
Other Product Names
ESX1 Antibody: ESX1L, ESXR1, ESX1L, ESX1R, Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
116241356
Physical Properties
Liquid

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