CALHM1 Antibody

CAT: 0223-5593-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-5593-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CALHM1 Antibody: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP) . The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
NCBI Gene ID
255022
Swiss Prot
Q8IU99
Accession Number
NP_001001412
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
CALHM1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1464 - Rat Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
CALHM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CALHM1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CALHM1
NCBI Official Name
Calcium homeostasis modulator 1
NCBI Organism
Homo sapiens
Background Reference 01
Mattson MP. Pathways towards and away from Alzheimer's disease. Nature2004; 430:631-9.
Background Reference 02
Dreses-Werringloer U, Lambert JC, Vingtdeux V, et al. A polymorphism in CALHM1 influences Ca2+ homeostasis, Ab levels, and Alzheimer 's disease risk. Cell2008; 133:1149-61.
Background Reference 03
Nacmias B, Tedde A, Bagnoli S, et al. Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer 's disease. J. Alzheimers Dis.2010; epub.
Other Product Names
CALHM1 Antibody: FAM26C, FAM26C, Calcium homeostasis modulator protein 1, Protein FAM26C
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
194440685
Physical Properties
Liquid

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