SYNGR3 Antibody

• Background:

  SYNGR3 Antibody: Synaptogyrins comprise a family of tyrosine-phosphorylated membrane proteins with two neuronal (SYNGR1 and SYNGR3) and one ubiquitous (SYNGR2) members. SYNGR1 and -3 are synaptic vesicle proteins, residing in some cases on the same synaptic vesicle, and are thought to be involved in the regulation of neurotransmitter release. SYNGR2, by contrast, is absent from synaptic vesicles. The role and localization of a fourth synaptogyrin, SYNGR4, is unclear. SYNGR3 is predominantly expressed in brain and placenta. SYNGR3 is involved in the positive regulation of dopamine transporter activity and facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release.

• NCBI Gene ID:

  9143

• Swiss Prot:

  O43761

• Accession Number:

  NP_004200

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  SYNGR3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1403 - Mouse Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (89%)

• Buffer:

  SYNGR3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SYNGR3 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  SYNGR3

• NCBI Official Name:

  Synaptogyrin 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Belizaire R, Komanduri C, Wooten K, et al. Characterization of synaptogyrin 3 as a new synaptic vesicle protein. J. Comp. Neurol.2004; 470:266-81.

• Background Reference 02:

  Egaña LA, Cuevas RA, Baust TB, et al. Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. J. Neurosci.2009; 29:4592-604.

• Other Product Names:

  SYNGR3 Antibody: Synaptogyrin-3

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  6631112

• Physical Properties:

  Liquid