PICALM Antibody

CAT: 0223-5553-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-5553-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PICALM Antibody: PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP) .
NCBI Gene ID
8301
Swiss Prot
Q13492
Accession Number
NP_009097
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
PICALM Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
PICALM Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PICALM antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
PICALM
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Phosphatidylinositol binding clathrin assembly protein
NCBI Organism
Homo sapiens
Background Reference 01
Tebar F, Bohlander SK, and Sorkin A. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin mediated traffic. Mol. Biol. Cell1999; 10:2687-702.
Background Reference 02
Caudell D and Aplan PD. The role of CALM-AF10 gene fusion in acute leukemia. Leukemia2008; 22:678-85.
Background Reference 03
Harel A, Wu F, Mattson MP, et al. Evidence for CALM in directing VAMP2 trafficking. Traffic2008; 9:417-29.
Background Reference 04
Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet.2009; 41:1088-93.
Other Product Names
PICALM Antibody: LAP, CALM, CLTH, Phosphatidylinositol-binding clathrin assembly protein, Clathrin assembly lymphoid myeloid leukemia protein
Tested Applications
ELISA, WB, IF
Protein ID
56788366
Physical Properties
Liquid

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