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MPYS Antibody

CAT: 0223-5269-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5269-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MPYS Antibody: MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.
NCBI Gene ID
340061
Swiss Prot
Q86WV6
Accession Number
NP_938023
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
5269
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 1) shows similar MPYS expression profile in human cell lines detected by two independent anti-MPYS antibodies that recognize different epitopes, 5269 against near C-terminus domain and 64-236 against C-terminus domain. MPYS proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines5269 64-236
Field of Research
Innate Immunity
Purification
MPYS Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1204 - K562 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat (82%), Bovine: (82%), Pig: (82%), Chicken: (71%)
Buffer
MPYS Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MPYS antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human MPYS has one isoform (379aa, 42kD) . Mouse MPYS has 3 isoforms, including isoform 1 (379aa, 42kD), isoform 2 (427aa, 48kD) and isoform 3 (337aa, 38kD) . Rat MPYS also has one isoform (379aa, 43kD) . 5269 can detect human, mouse and rat.
Symbol
TMEM173
Positive Control 2
Cat. No. 1205 - Jurkat Cell Lysate
Positive Control 3
Cat. No. 1288 - A20 Cell Lysate
Positive Control 4
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
Transmembrane protein 173
NCBI Organism
Homo sapiens
Background Reference 01
Jin et al. Mol. Cell. Biol.2008; 28:5014-26.
Background Reference 02
Zhong et al. Immunity2008; 29:538-50.
Other Product Names
MPYS Antibody: ERIS, MITA, MPYS, NET23, STING, ERIS, Stimulator of interferon genes protein, Endoplasmic reticulum interferon stimulator, hSTING
Tested Applications
ELISA, WB, ICC, IF
Protein ID
38093659
Physical Properties
Liquid

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Alternative Products

CatalogName
MBS9402514-01MPYS Antibody
APR06552GPolyclonal MPYS Antibody
A01871-1Anti-MPYS TMEM173 Antibody
OAPB00928-100UG-HRPMPYS Antibody : HRP (OAPB00928-HRP)
OAPB00928-100UG-FITCMPYS Antibody : FITC (OAPB00928-FITC)
OAPB00928-100UG-BiotinMPYS Antibody : Biotin (OAPB00928-Biotin)
MBS152282-01MPYS Peptide
136476TMEM173 (Transmembrane Protein 173, ERIS, FLJ38577, MITA, MPYS, NET23, STING) discontinued
MBS6440829-01TMEM173 (Transmembrane Protein 173, Endoplasmic Reticulum Interferon Stimulator, ERIS, MITA, MPYS, NET23, STING) (AP)
213820-01TMEM173 (Transmembrane Protein 173, Endoplasmic Reticulum Interferon Stimulator, ERIS, MITA, MPYS, NET23, STING) discontinued

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