CIP75 Antibody

• Background :

  CIP75 Antibody: The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.

• NCBI Gene ID :

  56893

• Swiss Prot :

  Q9NRR5

• Accession Number :

  Q9NRR5

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Homeostasis

• Purification :

  CIP75 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1282 - 3T3 (NIH) Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  CIP75 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  CIP75 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  UBQLN4

• NCBI Official Name :

  Ubiquilin 4

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Su V and Lau AF. Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation. Cell. Mol. Life Sci.2009; 66:2819-33.

• Background Reference 02 :

  Davidson JD, Riley B, Burright EN, et al. Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like protein. Hum. Mol. Genet.2000; 9:2305-12.

• Background Reference 03 :

  Li X, Su V, Kurata WE, et al. A novel Connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of Connexin4 J. Biol. Chem.2008; 283:5748-59.

• Other Product Names :

  CIP75 Antibody: A1U, A1Up, UBIN, CIP75, C1orf6, Ubiquilin-4, Ataxin-1 interacting ubiquitin-like protein

• Tested Applications :

  ELISA, WB, IHC-P

• Protein ID :

  45476982

• Physical Properties :

  Liquid