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SCARA5 Antibody

CAT: 0223-5259-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5259-01Size:0.02 mg
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Background
SCARA5 Antibody: Scavenger receptor class A member 5 (SCARA5), also known as TESR, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARA5 is a cell-surface receptor that contains the collagen-like domain and N-terminal scavenger receptor cysteine rich domain typical of the class A scavenger receptor subfamily. Unlike other class A receptors, SCARA5 does not endocytose acetylated or oxidized low density lipoprotein. Instead, SCARA5 binds serum ferritin and mediates its endocytosis from the cell surface, indicating SCARA5 may play a role in non-transferrin iron delivery.
NCBI Gene ID
286133
Swiss Prot
Q6ZMJ2
Accession Number
NP_776194
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
SCARA5 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (88%), Chicken: (86%), Rat: (80%)
Buffer
SCARA5 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SCARA5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least four isoforms of SCARA5 are known to exist; this antibody will detect all four isoforms.
Symbol
SCARA5
Positive Control 2
Cat. No. 17-011 - Hep G2 Cell Slide
NCBI Official Name
Scavenger receptor class A, member 5 (putative)
NCBI Organism
Homo sapiens
Background Reference 01
Greaves DR, Gough PJ, and Gordon S. Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence. Curr. Op. Lipid. 1998; 9:425-32.
Background Reference 02
Jiang Y, Oliver P, Davies KE, et al. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. J. Biol. Chem. 2006; 281:11834-45.
Background Reference 03
Li JY, Paragas N, Ned RM, et al. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev. Cell 2009; 16:35-46.
Other Product Names
SCARA5 Antibody: Tesr, NET33, Scavenger receptor class A member 5, Scavenger receptor hlg
Tested Applications
ELISA, WB, ICC, IF
Protein ID
47271477
Physical Properties
Liquid

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