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SCARB1 Antibody

CAT: 0223-5193-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5193-01Size:0.02 mg
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Background
SCARB1 Antibody: Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals. Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids. SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis. Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus.
NCBI Gene ID
949
Swiss Prot
Q8WTV0
Accession Number
Q8WTV0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Purification
SCARB1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (93%), Bovine: (80%)
Buffer
SCARB1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SCARB1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of SCARB1 are known to exist; this antibody can detect both isoforms.
Symbol
SCARB1
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Scavenger receptor class B, member 1
NCBI Organism
Homo sapiens
Background Reference 01
Greaves DR, Gough PJ, and Gordon S. Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence. Curr. Op. Lipid. 1998; 9:425-32.
Background Reference 02
Acton S, Rigotti A, Landschulz KT, et al. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 1996; 271:518-20.
Background Reference 03
Krieger M. Charting the fate of the "good cholesterol": identification and characterization of the HDL receptor SR-BI. Annu. Rev. Biochem. 1999; 68:523-88.
Background Reference 04
Trigatti B, Rayburn H, Vinals M, et al. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc. Natl. Acad. Sci. USA 1999; 96:9322-7.
Other Product Names
SCARB1 Antibody: CLA1, SRB1, CLA-1, SR-BI, CD36L1, HDLQTL6, CLA1, Scavenger receptor class B member 1, CD36 and LIMPII analogous 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
37999904
Physical Properties
Liquid

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