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THEM2 Antibody

CAT: 0223-5257-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5257-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
THEM2 Antibody: THEM2, also known as ACOT13, belongs to the hotdog-fold superfamily and possesses thioesterase activity, with greater activity observed with longer chain acyl-CoAs such as myristoyl- and palmitoyl-CoA. THEM2 is highly expressed in several tissues such as heart, kidney, liver and brain and has been shown to be co-localized with beta-tubulin on microtubules. THEM2 interacts with StarD, a protein that plays a key role in fatty acid metabolism, and the addition of StarD to THEM2 increased its catalytic activity, suggesting that THEM2 plays a significant role in the metabolism of fatty acids. At least two isoforms of THEM2 are known to exist.
NCBI Gene ID
55856
Swiss Prot
Q9NPJ3
Accession Number
NP_060943
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
THEM2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
1 mg/mL
Buffer
THEM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
THEM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ACOT13
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Acyl-CoA thioesterase 13
NCBI Organism
Homo sapiens
Background Reference 01
Cheng Z, Song F, Shan X, et al. Crystal structure of human thioesterase superfamily member 2. Biochem. Biophys. Res. Commun.2006; 349:172-7.
Background Reference 02
Wei J, Kang HW, and Cohen DE. Thioesterase superfamily member 2 (Them2) /acyl-CoA thioesterase 13 (Acot13) : a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs. Biochem. J.2009; 421:311-22.
Background Reference 03
Cheng Z, Bao S, Shan X, et al. Human thioesterase superfamily member 2 (hTHEM2) is co-localized with beta-tubulin onto the microtubule. Biochem. Biophys. Res. Commun.2006; 350:850-3.
Background Reference 04
Scappa EF, Pocai A, Wu MK, et al. Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD. FASEB J.2008; 22:2579-90.
Other Product Names
THEM2 Antibody: HT012, THEM2, PNAS-27, HT012, Acyl-coenzyme A thioesterase 13, Thioesterase superfamily member 2, Acyl-CoA thioesterase 13
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
8923812
Physical Properties
Liquid

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