EphA10 Antibody

• Background:

  EphA10 Antibody: Eph receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility of neuronal and endothelial cells in central nervous system function and in development. Eph receptors can be divided into two subgroups: EphA and EphB. In mammals, the EphA class consists of eight members (EphA 1-7 and 10) that in general bind to ephrin-A members linked to the cell membrane through a glycosylphosphatidylinositol linkage. The EphB class consists of six members (EphB 1-6) that in general bind ephrin-B members that transverse the cell membrane. The Ephrin / EPH signaling pathway networks with the WNT signaling pathway during embryogenesis, tissue regeneration, and carcinogenesis. Recent studies show that Eph/EFN might be relevant in normal B-cell biology and could represent new potential prognostic markers and therapeutic targets for CLL.

• NCBI Gene ID:

  284656

• Swiss Prot:

  Q5JZY3

• Accession Number:

  NP_001092909

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  EphA10 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  EphA10 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  EphA10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  EPHA10

• NCBI Official Name:

  EPH receptor A10

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Flanagan JG and Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci.1998; .21:309-45.

• Background Reference 02:

  Frisen J, Holmberg J, and Barbacid M. Ephrins and their Eph receptors: multitalented directors of embryonic development. EMBO J.1999; 18:5159-65.

• Background Reference 03:

  Eph Nomenclature Committee. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell1997; 90:403-4.

• Background Reference 04:

  Holder N and Klein R. Eph receptors and ephrins: effectors of morphogenesis, Development1999; 126:2033-44.

• Other Product Names:

  EphA10 Antibody: Ephrin type-A receptor 10

• Tested Applications:

  ELISA, WB

• Protein ID:

  150456460

• Physical Properties:

  Liquid