MC4R Antibody

• Background:

  MC4R Antibody: The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.

• NCBI Gene ID:

  4160

• Swiss Prot:

  P32245

• Accession Number:

  NP_005903

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Purification:

  MC4R Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (79%)

• Buffer:

  MC4R Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  MC4R antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  MC4R

• Positive Control 2:

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name:

  Melanocortin 4 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gantz I, Miwa H, Konda Y, et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem.1993; 268:15174-9.

• Background Reference 02:

  Vongs A, Lynn NM, and Rosenblum CI. Activation of MAP kinase by MC4-R through PI3 kinase. Regul. Pept.2004; 120:113-8.

• Background Reference 03:

  Cone H. Anatomy and regulation of the central melanocortin system. Nat. Neurosci.2005; 8:571-8.

• Background Reference 04:

  Chai B, Li J-Y, Zhang W, et al. Melanocartin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling. Peptides2009; 30:1098-10

• Other Product Names:

  MC4R Antibody: Melanocortin receptor 4, MC4-R

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  119508433

• Physical Properties:

  Liquid