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RSPO1 Antibody

CAT: 0223-5171-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5171-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RSPO1 Antibody: RSPO1 is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular beta-catenin, thereby regulating functions mediated by beta-catenin such as cell fate decisions and embryonic patterning. RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels.
NCBI Gene ID
284654
Swiss Prot
Q2MKA7
Accession Number
NP_001033722
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
5171
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 2) : Anti-RSPO1 antibodies (5171) detected human RSPO1 recombinant protein at different concentrations. Recombinant Protein Test5171
Field of Research
Signal Transduction
Purification
RSPO1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1224-Daudi Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat (100%) .
Buffer
RSPO1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RSPO1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of RSPO1 are known to exist; this antibody will detect the largest and smallest isoforms. RSPO1 antibody will not cross-react with other RSPO family members.
Isoform
Human RSPO1 has 3 isoforms, including isoform 1 (263aa, 29kD), isoform 2 (236aa, 26kD), and isoform 3 (200aa, 22kD) . Mouse RSPO1 had 1 isoform (265aa, 29kD) and rat RSPO1 had 1 isoform (262aa, 29kD) . 5171 can detect human, mouse and rat.
Symbol
RSPO1
Positive Control 2
Cat. No. 1301 - Human Heart Tissue Lysate
Positive Control 3
Cat. No. 10-501 - Human Heart Tissue Slide
Positive Control 4
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
R-spondin homolog (Xenopus laevis)
NCBI Organism
Homo sapiens
Background Reference 01
Kamata et al. Biochim. Biophys. Acta 2004; 1676:51-61.
Background Reference 02
Kim et al. Cell Cycle 2006; 5:23-6.
Background Reference 03
Parma et al. Nat. Genet. 2006; 38:1304-9.
Background Reference 04
Chassot et al. Hum. Mol. Genet. 2008; 17:1278-91.
Other Product Names
RSPO1 Antibody: RSPO, CRISTIN3, R-spondin-1, Roof plate-specific spondin-1, hRspo1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
84490388
Physical Properties
Liquid

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