Transthyretin Antibody

• Background:

  Transthyretin Antibody: Transthyretin is a tetrameric carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include familial amyloidotic polyneuropathy, euthyroid hyperthyroxinemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. It has also been suggested that Transthyretin plays an important role in the maintenance of normal cognitive processes during aging, neuropeptide processing and nerve regeneration. It has also been linked to several pathological conditions including Parkinson's disease, schizophrenia, and depression.

• NCBI Gene ID:

  7276

• Swiss Prot:

  P02766

• Accession Number:

  P02766

• Host:

  Chicken

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  Transthyretin Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (94%), Sheep: (88%), Rabbit: (82%), Pig: (82%)

• Buffer:

  Transthyretin Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Transthyretin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgY

• Symbol:

  TTR

• Positive Control 2:

  Cat. No. 10-101 - Human Lung Tissue Slide

• NCBI Official Name:

  Transthyretin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Fleming CE, Nunes AF, and Sousa MM. Transthyretin: more than meets the eye. Prog. Neurobiol.2009; 89:266-76.

• Background Reference 02:

  Fleming CE, Saraiva MJ, and Sousa MM. Transthyretin enhances nerve regeneration. J. Neurochem. 2007; 103:831-9.

• Background Reference 03:

  Rite I, Arguelles S, Venero JL, et al. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. J. Neurosci. Res. 2007; 85:3607-18.

• Other Product Names:

  Transthyretin Antibody: CTS, CTS1, PALB, TBPA, HEL111, HsT2651, Transthyretin, ATTR

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  136464

• Physical Properties:

  Liquid