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LRFN1 Antibody

CAT: 0223-5065-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5065-01Size:0.02 mg
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Background
LRFN1 Antibody: LRFN1 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR) -immunoglobulin-like (Ig) -fibronectin type III (Fn) -transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN1 are known to exist.
NCBI Gene ID
57622
Swiss Prot
Q9P244
Accession Number
Q9P244
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
LRFN1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
LRFN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LRFN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This antibody is predicted to not cross-react with other members of the LRFN family.
Symbol
LRFN1
NCBI Official Name
Leucine rich repeat and fibronectin type III domain containing 1
NCBI Organism
Homo sapiens
Background Reference 01
Morimura N, Inoue T, Katayama K, et al. Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins. Gene2006; 380:72-83.
Background Reference 02
Kobe B and Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol.2001; 11:725-32.
Background Reference 03
Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci.2003; 24:117-29.
Other Product Names
LRFN1 Antibody: SALM2, KIAA1484, SALM2, Leucine-rich repeat and fibronectin type III domain-containing protein 1, Synaptic adhesion-like molecule 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
189028858
Physical Properties
Liquid

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