LRFN4 Antibody

• Background:

  LRFN4 Antibody: LRFN4 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR) -immunoglobulin-like (Ig) -fibronectin type III (Fn) -transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN4 are known to exist.

• NCBI Gene ID:

  78999

• Swiss Prot:

  Q6PJG9

• Accession Number:

  Q6PJG9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  LRFN4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  LRFN4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  LRFN4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  This antibody is predicted to not cross-react with other members of the LRFN family.

• Symbol:

  LRFN4

• NCBI Official Name:

  Leucine rich repeat and fibronectin type III domain containing 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Morimura N, Inoue T, Katayama K, et al. Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins. Gene2006; 380:72-83.

• Background Reference 02:

  Kobe B and Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol.2001; 11:725-32.

• Background Reference 03:

  Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci.2003; 24:117-29.

• Other Product Names:

  LRFN4 Antibody: SALM3, SALM3., FIGLER6, SALM3, Leucine-rich repeat and fibronectin type-III domain-containing protein 4

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  62286924

• Physical Properties:

  Liquid