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KLRA2 Antibody

CAT: 0223-5017-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5017-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KLRA2 Antibody: KLRA2 (also known as Ly49B) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA2 is thought to be an inhibitory receptor and associates with the protein tyrosine phosphatases SHP1, SHP2, and SHIP in transfected cells. This antibody is predicted to not cross-react with other LY49 receptors.
NCBI Gene ID
16633
Swiss Prot
Q60660
Accession Number
Q60660
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
KLRA2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
KLRA2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KLRA2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
Klra2
NCBI Official Name
Killer cell lectin-like receptor, subfamily A, member 2
NCBI Organism
Mus musculus
Background Reference 01
Gosselin P, Lusignan Y, Brennan J, et al. The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles. Int. Immunol.1997; 533-40.
Background Reference 02
Smith HR, Karlhofer FM, and Yokoyama WM. Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol.1994; 153:1068-79.
Background Reference 03
Brennan J, Mager D, Jefferies W, et al. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J. Exp. Med.1994; 180:2287-95.
Background Reference 04
Saleh A, Davies GE, Pascal V, et al. Identification of probabilistic transcriptional switches in the Ly49 gene cluster: a eukaryotic mechanism for selective gene activation. Immunity2004; 21:55-66.
Other Product Names
KLRA2 Antibody: Ly49b, Klra30, Ly49-b, Ly49b, Killer cell lectin-like receptor 2, Lymphocyte antigen 49b, Ly-49b
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
2497636
Physical Properties
Liquid

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