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KLRA3 Antibody

CAT: 0223-4993-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4993-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KLRA3 Antibody: KLRA3 (also known as Ly49C) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA3 is thought to be an inhibitory receptor, recognizing peptide -receptive H-2Kb.
NCBI Gene ID
16634
Swiss Prot
Q64329
Accession Number
AAI32525
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
KLRA3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
KLRA3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KLRA3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This antibody may cross-react with other LY49 receptors.
Symbol
Klra3
NCBI Official Name
Killer cell lectin-like receptor, subfamily A, member 3
NCBI Organism
Mus musculus
Background Reference 01
Gosselin P, Lusignan Y, Brennan J, et al. The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles. Int. Immunol.1997; 533-40.
Background Reference 02
Smith HR, Karlhofer FM, and Yokoyama WM. Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol.1994; 153:1068-79.
Background Reference 03
Brennan J, Mager D, Jefferies W, et al. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J. Exp. Med.1994; 180:2287-95.
Background Reference 04
Su R-C, Kung SK, Silver ET, et al. Ly-49CB6 NK inhibitory receptor recognizes peptide-receptive H-2Kb. J. Immunol.1999; 163:5319-30.
Other Product Names
KLRA3 Antibody: 5E6, Nk2, Nk-2, Ly49c, Nk2.1, NK-2.1, Ly-49c, Ly49C, Killer cell lectin-like receptor 3, 5E6
Tested Applications
ELISA, WB
Protein ID
124376782
Physical Properties
Liquid

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