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TOM70 Antibody

CAT: 0223-4949-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4949-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TOM70 Antibody: The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear.
NCBI Gene ID
9868
Swiss Prot
O94826
Accession Number
NP_055635
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
4949
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 1) shows similar TOM70 expression profile in human, mouse and rat cell lines detected by two independent anti-TOM70 antibodies that recognize different epitopes, 4949 against N-terminus domain and 4959 against central domain. TOM70 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4949 4959
Field of Research
Homeostasis
Purification
TOM70 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
TOM70 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TOM70 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of TOM70 are known to exist; this antibody will only detect the larger isoform.
Isoform
Human TOM70 has only one isoform (608aa, 67.5kD. Mouse TOM70 has one isoform (611aa, 67.6kD) and Rat TOM70 also has one isoform (610aa, 67.4kD) . 4949 can detect human, mouse and rat.
Symbol
TOMM70A
Positive Control 2
Cat. No. 1202 - A431 lysate
Positive Control 3
Cat. No. 1224 - Daudi lysate
Positive Control 4
Cat. No. 1282 - 3T3/NIH lysate
NCBI Official Name
Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
NCBI Organism
Homo sapiens
Background Reference 01
Kutik et al. J. Cell Biol. 2007; 179:585-91.
Background Reference 02
Young et al. Cell 2003; 112:41-50.
Other Product Names
TOM70 Antibody: KIAA0719, TOM70, Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
54607135
Physical Properties
Liquid

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