Products for Research Use Only
RegisterLogin

ASAH2 Antibody

CAT: 0223-4743-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-4743-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
ASAH2 Antibody: Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.
NCBI Gene ID
56624
Swiss Prot
Q9NR71
Accession Number
NP_063946
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
ASAH2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
ASAH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ASAH2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ASAH2
NCBI Official Name
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
NCBI Organism
Homo sapiens
Background Reference 01
Nilsson A and Duan RD. Alkaline sphingomyelinases and ceramidases of the gastrointestinal tract. Chem. Phys. Lipids1999; 102:97-105.
Background Reference 02
Tani M, Okino N, Mitsutake S, et al. Molecular Cloning of the Full-length cDNA Encoding Mouse Neutral Ceramidase. J. Biol. Chem.2000; 275:11229-34.
Background Reference 03
Tani M, Iida H, and Ito M. O-Glycosylation of Mucin-like Domain Retains the Neutral Ceramidase on the Plasma Membranes as a Type II Integral Membrane Protein. J. Biol. Chem.2003; 278:10523-30.
Background Reference 04
Osawa Y, Uchinami H, Bielawski J, et al. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J. Biol. Chem.2005; 280:27879-87.
Other Product Names
ASAH2 Antibody: HNAC1, BCDase, LCDase, NCDase, N-CDase, HNAC1, Neutral ceramidase, Acylsphingosine deacylase 2
Tested Applications
ELISA, WB
Protein ID
221218981
Physical Properties
Liquid

Related Products

CatalogName
4743PASAH2 Peptide
4741-01ASAH1 Antibody
16-991ASAP2 Antibody
4741-002mgASAH1 Antibody
26-026ASAHL Antibody
4741-01mgASAH1 Antibody
4741PASAH1 Peptide
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody

Alternative Products

CatalogName
MBS8589590-01ASAH2 Antibody

Popular Products