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CSN8 Antibody

CAT: 0223-4601-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4601-01Size:0.02 mg
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Background
CSN8 Antibody: The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
NCBI Gene ID
10920
Swiss Prot
Q99627
Accession Number
NP_006701
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
CSN8 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
CSN8 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CSN8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
COPS8
NCBI Official Name
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
NCBI Organism
Homo sapiens
Background Reference 01
Wei N and Deng XW. The COP9 signalosome. Annu. Rev. Cell Dev. Biol.2003; 19:261-86.
Background Reference 02
Bech-Otschir D, Seeger M, and Dubiel W. The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis. J. Cell Sci.2002; 115:467-73.
Background Reference 03
Groisman R, Polanowska J, Kuraoka I, et al. The ubiquitin ligase activity in the DDB2 and regulated by the COP9 signalosome in response to DNA damage. Cell2003; 113:357-67.
Background Reference 04
Uhle S, Medalia O, Waldron R, et al. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J.2003; 22:1302-12.
Other Product Names
CSN8 Antibody: COP9, CSN8, SGN8, COP9 signalosome complex subunit 8, COP9 homolog
Tested Applications
ELISA, WB
Protein ID
5729779
Physical Properties
Liquid

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