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NPTX2 Antibody

CAT: 0223-4573-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4573-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NPTX2 Antibody: Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD. This NPTX2 antibody is predicted to be specific to NPTX2 and not recognize NPTX1.
NCBI Gene ID
4885
Swiss Prot
P47972
Accession Number
NP_002514
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
4573
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar NPTX2 expression profile in human and mouse cell lines detected by two independent anti-NPTX2 antibodies that recognize different epitopes, 4573 against central domain and 64-234 against another central domain. NPTX2 proteins are detected only in HeLa and HepG2 cell lines by the two independent antibodies. Independent Antibody Validation in Cell lines4573 64-234
Field of Research
Neuroscience
Purification
NPTX2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Guinea pig: (88%)
Buffer
NPTX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NPTX2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human NPTX2 has one isoform (431aa, 47kD) . Mouse NPTX2 has one isoform (429aa, 47.1kD) and Rat NPTX2 also has one isoform (432aa, 47.4kD) . 4573 can detect human, mouse and rat.
Symbol
NPTX2
Positive Control 2
Cat. No. 1201 – HeLa Cell Lysate
Positive Control 3
Cat. No. 1211 – HepG2 Cell Lysate
Positive Control 4
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Neuronal pentraxin II
NCBI Organism
Homo sapiens
Background Reference 01
Hsu and Perin. Genomics1995; 28:220-7.
Background Reference 02
Tsu et al. J. Neurosci.1996; 16:2463-78.
Background Reference 03
Xu et al. Neuron2003; 39:513-28.
Background Reference 04
Moran et al. Acta Neuropathol.2008; 115:471-8.
Other Product Names
NPTX2 Antibody: NP2, NARP, NP-II, Neuronal pentraxin-2, Neuronal pentraxin II, NP2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
28195384
Physical Properties
Liquid

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