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RIM2 Antibody

CAT: 0223-4445-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4445-01Size:0.02 mg
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Background
RIM2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM1 and RIM2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM1, RIM2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
NCBI Gene ID
9699
Swiss Prot
Q9UQ26
Accession Number
NP_001093587
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
RIM2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)
Buffer
RIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RIM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 148 kDa
Fragment
IgG
Symbol
RIMS2
NCBI Official Name
Regulating synaptic membrane exocytosis 2
NCBI Organism
Homo sapiens
Background Reference 01
Wang Y, Sugita S, and Sudhof TC. The RIM/NIM family of neuronal C2 domain proteins: interactions with Rab3 and a new class of Src homology 3 domain proteins. J. Biol. Chem. 2000; 275:20033-44.
Background Reference 02
Liang F, Zhang B, Tang J, et al. RIM3gamma is a postsynaptic protein in the rat central nervous system. J. Comp. Neurol. 2007; 503:501-10
Background Reference 03
Shoch S, Mittelstaedt T, Kaeser PS, et al. Redundant functions of RIM1α and RIM2α in Ca2+-triggered neurotransmitter release. EMBO J. 2006; 25:5852-63.
Other Product Names
RIM2 Antibody: OBOE, RIM2, RAB3IP3, KIAA0751, Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2
Tested Applications
ELISA, IHC-P
Protein ID
154354983
Physical Properties
Liquid

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