TEM2 Antibody

• Background:

  TEM2 Antibody: Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.

• NCBI Gene ID:

  23551

• Swiss Prot:

  Q96D21

• Accession Number:

  Q96D21

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  TEM2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1320 - Human Colon Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  TEM2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TEM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  RASD2

• NCBI Official Name:

  RASD family, member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vargiu P, Morte B, Manzano J, et al. Thyroid hormone regulation of rhes, a novel RAS homolog gene expressed in the striatum. Brain Res. Mol. Brain Res.2001; 94:1-8.

• Background Reference 02:

  Spano D, Branchi I, Rosica A, et al. Rhes is involved in striatal function. Mol. Cell. Biol.2004; 24:5788-96.

• Background Reference 03:

  Carson-Walter EB, Watkins DN, Nanda A, et al. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res.2001; 61:6649-55.

• Background Reference 04:

  Yamamoto Y, Irie K, Nanda A, et al. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene2004; 23:3889-97.

• Other Product Names:

  TEM2 Antibody: Rhes, TEM2, MGC:4834, GTP-binding protein Rhes, Ras homolog enriched in striatum

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  21362868

• Physical Properties:

  Liquid