TEM7 Antibody

CAT: 0223-4339-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4339-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TEM7 Antibody: Tumor endothelial marker 7 (TEM7) was identified through serial analysis of gene expression on endothelial cells isolated from human normal and malignant colorectal tissues. Further experiments verified TEM7 was highly expressed in the endothelium of numerous other cancer types including breast, lung and brain tumors. At least four isoforms of TEM7 are known to exist; these include intracellular, secreted, and membrane-bound forms. A homologous protein, TEM7R (also known as PLXDC2), acts as a binding partner to TEM7 and is also abundantly expressed in the endothelium of malignant colorectal cancer but is absent or rare in normal colon mucosa. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
NCBI Gene ID
57125
Swiss Prot
Q8IUK5
Accession Number
AAG00869
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
TEM7 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
TEM7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TEM7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
PLXDC1
NCBI Official Name
Plexin domain containing 1
NCBI Organism
Homo sapiens
Background Reference 01
St. Croix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science2000; 289:1197-202.
Background Reference 02
Nanda A, Buckhaults P, Seaman S, et al. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Cancer Res.2004; 64:8507-11.
Background Reference 03
Carson-Weber EB, Watkins DN, Nanda A, et al. Cell surface tumor epithelial markers are conserved in mice and humans. Cancer Res.2001; 61:6649-55.
Background Reference 04
Fuchs B, Mahlum E, Halder C, et al. High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma. Gene2007; 399:137-43.
Other Product Names
TEM7 Antibody: TEM3, TEM7, TEM3, Plexin domain-containing protein 1, Tumor endothelial marker 3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
14017379
Physical Properties
Liquid

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