Op18 Antibody

CAT: 0223-4235-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4235-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Op18 Antibody: Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.
NCBI Gene ID
3925
Swiss Prot
P16949
Accession Number
AAH82228
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
4235
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar op18 expression profile in human, mouse and rat cell lines detected by two independent anti-op18 antibodies that recognize different epitopes, 4235 against C-terminus domain and 4237 against N-terminus domain. op18 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4235 4237
Field of Research
Homeostasis
Purification
Op18 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%), Chicken: (95%)
Buffer
Op18 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Op18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human op18 has 2 isoforms, including isoform 1 (149aa, 17kD) and isoform 2 (174aa, 20kD) . Mouse op18 has one isoform (149aa, 17kD) and rat op18 also has one isoform (149aa, 17kD) . 4235 can detect only human isoform 1and it can also detect mouse and rat op18.
Symbol
STMN1
Positive Control 2
Cat. No. 1303 - Human Brain Tissue Lysate
Positive Control 3
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
STMN1
NCBI Organism
Homo sapiens
Background Reference 01
Curmi et al. Cell Structure and Function 1999; 24:345-57.
Background Reference 02
Belmont et al. Cell 1996; 84:623-31.
Background Reference 03
Mizumura et al. J. Cell Physiol. 2006; 206:363-70.
Background Reference 04
Mistry et al. Mount Sinai J. Med. 2002; 69:299-304.
Other Product Names
Op18 Antibody: Lag, SMN, OP18, PP17, PP19, PR22, LAP18, C1orf215, Stathmin, Leukemia-associated phosphoprotein p18, Op18
Tested Applications
ELISA, WB, IHC-P
Protein ID
51895905
Physical Properties
Liquid

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