Products for Research Use Only
RegisterLogin

TBC1D1 Antibody

CAT: 0223-4231-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-4231-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
TBC1D1 Antibody: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.
NCBI Gene ID
23216
Swiss Prot
Q86TI0
Accession Number
NP_055988
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Signal Transduction, Cancer
Purification
TBC1D1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 – 293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (71%)
Buffer
TBC1D1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TBC1D1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TBC1D1
NCBI Official Name
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
NCBI Organism
Homo sapiens
Background Reference 01
White RA, Pasztor LM, Richardson PM, et al. The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, Bub2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. Cytogenet. Cell Genet.2000; 89:272-5.
Background Reference 02
Koumanov F and Holman GD. Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways. Biochem. J.2007; 403:e9-11.
Background Reference 03
Roach WG, Chavez JA, Miinea CP, et al. Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. Biochem J.2007; 403:353-8.
Background Reference 04
Stone S, Abkevich V, Russell DL, et al. TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum. Mol. Genet.2006; 15:2709-20.
Other Product Names
TBC1D1 Antibody: TBC, TBC1, KIAA1108, TBC1 domain family member 1
Tested Applications
ELISA, WB
Protein ID
50658061
Physical Properties
Liquid

Related Products

CatalogName
4231PTBC1D1 Peptide
56-093TBC1D13 Antibody
43-465TBC1D9 Antibody
4415-002mgTBC1D4 Antibody
4415-01TBC1D4 Antibody
57-879TBC1D21 Antibody
59-995TBC1D2 Antibody
58-786TBC1D8 Antibody
4415-01mgTBC1D4 Antibody
55-267TBCCD1 Antibody

Alternative Products

CatalogName
GTR17896778-01TBC1D1 Antibody

Popular Products